Dedifferentiated Gastrointestinal Stromal Tumor

Preferred Label : Dedifferentiated Gastrointestinal Stromal Tumor;

NCIt definition : A gastrointestinal stromal tumor that through the process of dedifferentiation, results in an uncommon phenotype. Dedifferentiation in the context of GIST, may manifest as loss of CD117 expression and regression from specialized tissue to a more anaplastic/pleomorphic appearance, high nuclear atypia, high mitotic activity, and necrosis.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1662626;

Details

Origin ID

C179932;

UMLS CUI

C5555955;

Disease excludes normal cell origin
- Epithelial Cell [NCIt concept]
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
Disease may have findings
- Lesion with Diameter Greater than 10 cm [NCIt concept]
Excludes anatomical site(s)
- Bone [NCIt concept]
Has associated anatomic sites
- Connective and Soft Tissue [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Intermediate Filaments Present [NCIt concept]
- Intracytoplasmic Eosinophilic Inclusion [NCIt concept]
disease_excludes_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Connective and Soft Tissue Cell [NCIt concept]
- Neoplastic Stromal Cell [NCIt concept]
disease_has_finding
- Dedifferentiated Lesion [NCIt concept]
- High Grade Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- More than 5 Mitoses per 50 HPF [NCIt concept]
disease_has_normal_cell_origin
- Connective and Soft Tissue Cell [NCIt concept]
- Interstitial Cell of Cajal [NCIt concept]
- Stromal Cell [NCIt concept]
disease_has_normal_tissue_origin
- Connective and Soft Tissue [NCIt concept]
- Soft Tissue [NCIt concept]
disease_mapped_to_gene
- KIT Gene [NCIt concept]
- PDGFRA Gene [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Loss of Chromosome 14 [NCIt concept]
- Loss of Chromosome 1p [NCIt concept]
- Loss of Chromosome 22 [NCIt concept]
disease_may_have_molecular_abnormality
- KIT Gene Mutation [NCIt concept]
- PDGFRA Gene Mutation [NCIt concept]

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