miR-221 LNA Inhibitor LNA-i-miR-221

Preferred Label : miR-221 LNA Inhibitor LNA-i-miR-221;

NCIt synonyms : miR-221 Locked Nucleic Acid-based Antisense Oligonucleotide LNA-i-miR-221; miR-221 LNA ASO LNA-i-miR-221; LNA-i-miR-221;

NCIt definition : A phosphorothioate (PS) modified backbone 13-mer locked nucleic acid (LNA)-based antisense oligonucleotide (ASO) and inhibitor of the oncogenic microRNA (miRNA) miR-221, with potential chemo-sensitizing and antineoplastic activities. Upon administration, miR-221 LNA inhibitor LNA-i-miR-221 hybridizes with endogenous miR-221 and inhibits miR-221-mediated functions involving tumor cell proliferation, angiogenesis and metastasis, and the modulation of drug influx-efflux transporters as it regulates the expression of a variety of target genes. miR-221, oncogenic miRNA that is upregulated in various malignancies, plays important roles in tumor cell proliferation, angiogenesis and metastasis, and in the development of drug resistance such as melphalan resistance.;

NCI Metathesaurus CUI : CL1662449;

Details

Origin ID

C179741;

UMLS CUI

C3883902;

Automatic exact mappings (from CISMeF team)
- LNA-i-miR-221 [MeSH Supplementary Concept]
- LNA-i-miR-221 [MeSH concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- LNA-i-miR-221 [MeSH Supplementary Concept]
- LNA-i-miR-221 [MeSH concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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