Preferred Label : Indium In 111 Panitumumab;
NCIt synonyms : 111In Panitumumab; 111In-panitumumab; In 111-panitumumab;
NCIt definition : A radioimmunoconjugate composed of panitumumab, a human immunoglobulin G2 (IgG2) monoclonal
antibody directed against the epidermal growth factor receptor (EGFR; HER1; ErbB1),
labeled with the radioisotope indium In 111, with potential use as an imaging agent
upon single photon emission computed tomography/computed tomography (SPECT/CT). Upon
administration of Indium In 111 panitumumab, the antibody moiety targets and binds
to the extracellular domain of EGFR on tumor cells. Upon SPECT/CT imaging, EGFR-expressing
tumor cells can be visualized and assessed. EGFR, a receptor tyrosine kinase overexpressed
on the cell surfaces of many tumor cell types, plays a key role in tumor cell proliferation.;
NCI Metathesaurus CUI : CL1662464;
Origin ID : C179734;
UMLS CUI : C5555881;
Semantic type(s)
- concept_is_in_subset
- has_target
