Preferred Label : Detalimogene Voraplasmid;
NCIt synonyms : Dually Derivatized Chitosan Nanoparticles-encapsulated IL-12 and RIG-I Activating
DNA Plasmid EG-70; DDX Nanoparticles-encapsulated IL-12 and RIG-I Activating DNA Plasmid EG-70;
NCIt definition : A nanoparticle-based formulation composed of a non-viral plasmid DNA vector encoding
the human pro-inflammatory cytokine interleukin-12 (IL-12) and a retinoic acid-inducible
gene I protein (RIG-I; DDX58) activating moiety encapsulated in dually derivatized
chitosan (DDX) nanoparticles, with potential immunostimulating and antineoplastic
activities. Upon intravesical administration of detalimogene voraplasmid, the DDX
nanoparticles deliver the IL-12 and RIG-I activating DNA plasmid to the bladder urothelium.
This leads to local expression of IL-12 and a RIG-I activating moiety. The increased
IL-12 production at the tumor site activates the immune system by promoting the activation
of natural killer cells (NKs), inducing secretion of interferon-gamma (IFN-g) and
promoting cytotoxic T-lymphocyte (CTL) responses against tumor cells. The RIG-I activating
moiety activates the cytosolic RNA receptor RIG-I and induces RIG-I-mediated signaling.
This upregulates interferon-alpha (IFN-a) and beta (IFN-b), and induces a potent IFN-mediated
innate immune response against the tumor cells. This further induces the activation
of NKs and CTLs and induces apoptosis in cancer cells.;
UNII : X3KB597LMN;
CAS number : 2660044-23-3;
Molecule name : EG 70; EG-70;
NCI Metathesaurus CUI : CL1662401;
Origin ID : C179685;
UMLS CUI : C5783405;
Semantic type(s)
- concept_is_in_subset
