Preferred Label : Oncolytic Adenovirus ICOVIR5-infected Allogeneic Mesenchymal Stem Cells;
NCIt synonyms : Oncolytic Adenovirus ICOVIR5-infected Allogeneic MSCs;
NCIt definition : A preparation of bone marrow-derived allogeneic mesenchymal stem cells (MSCs) infected
with the oncolytic, replication-competent adenovirus ICOVIR5, with potential antineoplastic
activity. Upon infusion of the oncolytic adenovirus ICOVIR5-infected allogeneic MSCs,
these cells target the adenovirus to tumors. The oncolytic virus then selectively
transfects and replicates in the tumor cells causing a direct cytotoxic effect and
lysis of the tumor cells. In addition, the viral infection and the subsequent release
of tumor-associated antigens (TAAs) upon lysis may stimulate an immune response against
the tumor cells. This may lead to an inhibition of cancer cell proliferation. ICOVIR-5,
a virus derived from wild-type human adenovirus serotype 5 (Had5), has been modified
to selectively replicate in tumor cells that have a deregulated retinoblastoma/E2F
pathway.;
Drug name : AloCelyvir;
NCI Metathesaurus CUI : CL1662394;
Origin ID : C179678;
UMLS CUI : C5555864;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
