Preferred Label : DNA Repair Inhibiting Oligonucleotide;
NCIt synonyms : DNA Repair Inhibiting Oligonucleotide AsiDNA; Oligonucleotide-mimicking Double-stranded DNA Breaks; DSBs Mimic;
NCIt definition : A preparation of cell-permeant, short double-stranded DNA fragment that mimics double-strand
breaks and linked to a cholesterol molecule, with potential antineoplastic activity.
Upon administration of DNA repair inhibiting oligonucleotide, the cholesterol moiety
enables tumoral and nuclear uptake of the DNA, and mimics DNA double-strand breaks
(DSBs) inside the tumor cells. This triggers false DNA break signals, binding to and
activating DNA repair proteins including both poly (ADP-ribose) polymerase (PARP)
and DNA-dependent protein kinase (DNA-PK). This prevents the recruitment of these
repair proteins at the actual damage site and inhibits various DNA DSB repair pathways
including homologous recombination (HR) and non-homologous end joining (NHEJ). This
promotes genetic instability and enhances the accumulation of single and double strand
DNA breaks, ultimately leading to apoptosis.;
Drug name : AsiDNA;
NCI Metathesaurus CUI : CL1662411;
Origin ID : C179671;
UMLS CUI : C5555860;
Semantic type(s)
- concept_is_in_subset
