Preferred Label : Autologous CMV-pp65-LAMP mRNA Loaded Monocyte Vaccine MT-201-GBM;
NCIt synonyms : Monocyte Antigen Carrier Cells MT-201-GBM;
NCIt definition : A cancer cell vaccine consisting of autologous monocytes loaded with mRNA encoding
the human cytomegalovirus (CMV) matrix protein pp65 (65 kDa lower matrix phosphoprotein;
UL83) as a fusion protein with the lysosome-associated membrane protein (LAMP), with
potential immunostimulatory and antineoplastic activities. Upon administration, the
autologous CMV-pp65-LAMP mRNA loaded monocyte vaccine MT-201-GBM exposes the immune
system to the CMV pp65 peptide, which may elicit a cytotoxic T-lymphocyte (CTL) response
against CMV pp65-expressing tumor cells. The incorporation of LAMP may route CMV pp-65
antigens into the lysosomal compartment, resulting in enhanced MHC class II antigen
presentation, thereby promoting CD4-positive T-cell responses. The CMV pp65 protein
is the primary component of the enveloped subviral particle of CMV and is expressed
in certain tumor types.;
Molecule name : MT 201-GBM; MT201-GBM;
NCI Metathesaurus CUI : CL1662412;
Origin ID : C179670;
UMLS CUI : C5555859;
Semantic type(s)
- concept_is_in_subset
- has_target
