Preferred Label : Ex Vivo-expanded Allogeneic Gamma 9 Delta 2 T-cells;
NCIt synonyms : Ex-vivo Expanded Allogeneic Gamma9-delta2 T Cells;
NCIt definition : A preparation of a subset of ex vivo-expanded, allogeneic T-lymphocytes that express
gamma 9 delta 2 T-cell receptors (TCRs), with potential immunomodulating and antineoplastic
activities. Upon administration of the ex vivo-expanded allogeneic gamma 9 delta 2
T-cells, these cells secrete interferon-gamma (IFN-g) and exert direct killing of
tumor cells. In addition, these cells activate the immune system to exert a cytotoxic
T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a
key role in the activation of the immune system and do not require major histocompatibility
complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. Gamma
9 delta 2 T-cells, a subset of gamma delta T-cells, may have a stronger association
with antitumor immune responses compared with other gamma delta T-cell subtypes.;
NCI Metathesaurus CUI : CL1662406;
Origin ID : C179664;
UMLS CUI : C5555854;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
