Preferred Label : Gallium Ga 68-NOTA-FAPI-04;
NCIt synonyms : 68Ga-NOTA-FAPI-04; 68Ga-NOTA-FAPI04; Gallium Ga 68-NOTA-FAPI04;
NCIt definition : A radioconjugate composed of FAPI-04, a quinoline-based fibroblast activation protein
(FAP)-targeted tracer belonging to the group of FAP inhibitors (FAPi), conjugated
with the bifunctional, macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic
acid (NOTA) and labeled with the radionuclide gallium Ga 68, with potential use as
a tracer for FAP-expressing cancer-associated fibroblasts (CAFs) during positron emission
tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68-NOTA-FAPI-04,
the FAPI-04 moiety targets and binds to FAP-expressing CAFs. Upon binding, FAP-expressing
cells can be detected during PET/CT imaging. FAP, a cell surface protein, is overexpressed
on CAFs in the tumor microenvironment (TME).;
NCI Metathesaurus CUI : CL1662407;
Origin ID : C179659;
UMLS CUI : C5555850;
Semantic type(s)
- concept_is_in_subset
- has_target
