Preferred Label : TBX-4000-treated Hematopoietic Stem Cells TBX-2400;
NCIt synonyms : HSCs TBX-2400;
NCIt definition : An allogeneic cell preparation in which donor-derived hematopoietic stem cells (HSCs)
are treated ex vivo with TBX-4000, a recombinant TAT-MYC fusion protein, with potential
immunoreconstitutive activity. Upon administration, the TBX-4000-treated HSCs TBX-2400
may enhance the engraftment of the bone marrow upon allogeneic hematopoietic stem
cells transplant (HSCT). The TBX-4000 recombinant fusion protein consists of the N-terminal
9 amino acid segment of the HIV TAT protein transduction domain (PTD) fused to the
MYC protein. TBX-4000 TAT-MYC rapidly localizes to the nucleus and transiently provides
signals to drive proliferation and survival of the HSCs.;
Molecule name : TBX-2400; TBX 2400;
NCI Metathesaurus CUI : CL1662156;
Origin ID : C179636;
UMLS CUI : C5555831;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
