Preferred Label : Norcantharidin Lipid Microspheres;
NCIt synonyms : NCTD Lipid Microspheres;
NCIt definition : A formulation composed of lipid microspheres encapsulating the demethylated derivative
of cantharidin and poorly water soluble norcantharidin (NCTD), with potential immunomodulating
and antineoplastic activities. Upon administration of the NCTD lipid microspheres,
NCTD modulates the expression and activity of numerous proteins and signaling pathways
involved in tumor cell proliferation, invasion, metastasis, and angiogenesis. This
induces cell cycle arrest and apoptosis, promotes tumor cell demethylation, inhibits
cell proliferation, modulates immune responses, inhibits epithelial-mesenchymal transition
(EMT), and inhibits invasion, metastasis, and angiogenesis in susceptible tumor cells.;
NCI Metathesaurus CUI : CL1662157;
Origin ID : C179615;
UMLS CUI : C5555816;
Semantic type(s)
- concept_is_in_subset
