Preferred Label : Capsase-9-PP2A Interaction Inhibitor PEP-010;
NCIt synonyms : Cell Penetrating and Capsase-9/PP2A Interaction Interfering Peptide PEP-010; Cell Penetrating and Interfering Peptide PEP-010; Capsase-9/PP2A Interaction Interfering Peptide PEP-010;
NCIt definition : A cell penetrating and interfering peptide composed of a cell-penetrating part that
delivers the peptide into the cellular cytosol and an interfering part that inhibits
the interaction between the proteins intracellular caspase-9 and protein phosphatase
2A (PP2A) proteins, with potential antineoplastic activity. Upon administration, the
cell-penetrating part of capsase-9-PP2A interaction inhibitor PEP-010 delivers the
peptide into the cellular cytosol and the interfering part of PEP-010 disrupts the
interaction between intracellular caspase-9 and PP2A. This leads to the release and
the activation of caspase-9, thereby restoring tumor cell apoptosis. Activated caspase-9
is involved in the induction of caspase-dependent apoptosis. PP2A, a serine/threonine
phosphatase, plays a key role in the control of cell growth and DNA damage repair.;
Molecule name : PEP-010; PEP 010;
NCI Metathesaurus CUI : CL1662163;
Origin ID : C179613;
UMLS CUI : C5555814;
Semantic type(s)
- concept_is_in_subset
