Preferred Label : miRNA 193a-3p Mimic INT-1B3;
NCIt synonyms : microRNA 193a-3p Mimic INT-1B3; Lipid Nanoparticle Encapsulating miR-193a-3p Mimic INT-1B3;
NCIt definition : A synthetic microRNA (miRNA) mimic of the endogenous tumor suppressor miR-193a-3p
formulated in lipid nanoparticles (LNPs), with potential antineoplastic and immune-activating
activities. Upon administration, miRNA-193a-3p mimic INT-1B3 targets tumor cells,
binds to its target sequence in mRNA transcripts, which leads to translational repression
or mRNA degradation. This inhibits protein expression encoded by that particular mRNA
sequence. INT-1B3 is able to downregulate many oncogenic signaling pathways, such
as the oncogenic PI3K/Akt and Ras/MAPK pathways, and upregulate the tumor suppressive
PTEN pathway. INT-1B3 also modulates the expression of cyclin D1, Mcl-1, K-Ras, c-Kit
and TIM-3. In addition, INT-1B3 is able to modulate the tumor microenvironment (TME)
through inhibition of CD39/CD73 and by downregulating the adenosine-A2A receptor pathway.
This leads to a decrease in immunosuppressive FoxP3/Lag3 regulatory T cells and monocytic
myeloid-derived suppressor cells (mMDSCs), increases the maturation of dendritic cells
(DCs) and induces a T cell-mediated anti-tumor immune response. Altogether, this may
induce cell cycle arrest and apoptosis, increase cell senescence, and decrease tumor
cell proliferation, survival, migration and metastasis.;
Molecule name : INT 1B3; INT-1B3;
NCI Metathesaurus CUI : CL1662186;
Origin ID : C179581;
UMLS CUI : C5555788;
Semantic type(s)
- concept_is_in_subset
