Preferred Label : Oncolytic Adenovirus AdAPT-001;
NCIt synonyms : Oncolytic Virus AdAPT-001;
NCIt definition : A replication competent human attenuated adenoviral vector, TAV-255, modified to express
a human transforming growth factor beta (TGF-b) trap fusion protein that neutralizes
TGF-b, with potential oncolytic, immunomodulating and antineoplastic activities. Upon
administration, oncolytic adenovirus AdAPT-001 selectively binds to and replicates
in tumor cells and induces tumor cell lysis. In addition, tumor cell lysis releases
a variety of tumor-associated antigens (TAAs) which may potentially result in the
activation of a systemic immune response against the TAAs-expresssing tumor cells.
AdAPT-001 has been attenuated to prevent replication in healthy cells.;
Molecule name : AdAPT-001; AdAPT 001;
NCI Metathesaurus CUI : CL1662089;
Origin ID : C179574;
UMLS CUI : C5555781;
Semantic type(s)
- concept_is_in_subset
