Preferred Label : Fisetin;
NCIt synonyms : 7,3',4'-Flavon-3-ol; 3,3',4',7-Tetrahydroxyflavone;
NCIt definition : An orally bioavailable naturally occurring polyphenol found in many fruits and vegetables,
with potential antioxidant, neuroprotective, anti-inflammatory, antineoplastic, senolytic,
and longevity promoting activities. Upon administration, fisetin, as an antioxidant,
scavenges free radicals, protect cells from oxidative stress, and is able to upregulate
glutathione. It inhibits pro-inflammatory mediators, such as tumor necrosis factor
alpha (TNF-a), interleukin-6 (IL-6), and nuclear factor kappa B (NF-kB). Fisetin promotes
cellular metabolism, reduces senescence, regulates sirtuin function and may promote
longevity. Fisetin also exerts anti-cancer activity by inhibiting certain signaling
pathways. It also inhibits certain anti-apoptotic proteins and induces apoptosis in
susceptible cells.;
UNII : OO2ABO9578;
CAS number : 528-48-3;
NCI Metathesaurus CUI : CL1662093;
Origin ID : C179571;
UMLS CUI : C0060397;
Automatic exact mappings (from CISMeF team)
- fisetin [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- fisetin [MeSH Supplementary Concept]
- concept_is_in_subset
