Preferred Label : Menin-MLL Interaction Inhibitor JNJ-75276617;
NCIt synonyms : Menin-MLL1 Interaction Inhibitor JNJ-75276617; Menin-KMT2A Interaction Inhibitor JNJ-75276617;
NCIt definition : An orally bioavailable protein-protein interaction (PPI) inhibitor of the menin-mixed
lineage leukemia (MLL; mixed-lineage leukemia 1; MLL1; myeloid/lymphoid leukemia;
histone-lysine N-methyltransferase 2A; KMT2A) proteins, with potential antineoplastic
activity. Upon oral administration, menin-MLL interaction inhibitor JNJ-75276617 inhibits
the interaction between the two proteins menin and MLL and the formation of the menin-MLL
complex. This reduces the expression of downstream target genes and results in an
inhibition of the proliferation of leukemic cells with either KMT2A alterations such
as gene rearrangements (KMT2A-r), duplications, and amplification, or nucleophosmin
1 gene (NPM1) alterations. The menin-MLL complex plays a key role in the survival,
growth, transformation and proliferation of certain kinds of leukemia cells.;
Molecule name : JNJ 75276617; JNJ-75276617;
NCI Metathesaurus CUI : CL1662086;
Origin ID : C179561;
UMLS CUI : C5555772;
Semantic type(s)
- concept_is_in_subset
