Preferred Label : Engineered Red Blood Cells Expressing HPV16 E7/4-1BBL/IL-12 RTX-321;
NCIt synonyms : HPV aAPC RTX-321; Engineered RBCs Expressing HPV16 E7/4-1BBL/IL-12 RTX-321; Allogeneic aAPCs-expressing HPV16 E7/4-1BBL/IL-12 RTX-321; Allogeneic Artificial Antigen-presenting Cells-expressing HPV16 E7/4-1BBL/IL-12 RTX-321;
NCIt definition : A preparation of allogeneic red blood cells (RBCs) engineered to act as artificial
antigen presenting cells (aAPCs) and express on the cell surface the human papillomavirus
(HPV) type 16 E7 protein on the major histocompatibility complex (MHC) I, the co-stimulatory
molecule tumor necrosis factor ligand superfamily (TNFSF) member 9 (TNFSF9; 4-1BBL)
and the immunostimulatory cytokine interleukin-12 (IL-12), with potential immunomodulating
and antineoplastic activities. Upon administration of the engineered RBCs expressing
HPV16 E7/4-1BBL/IL-12 RTX-321, these cells activate the immune system to mount a cytotoxic
T-lymphocyte (CTL) immune response against tumor cells expressing HPV16 E7. In addition,
4-1BBL and IL-12 expressed on these cells bind to 4-1BB and IL-12 receptors and subsequently
induce the proliferation and activation of natural killer (NK) cells and T-cells.
This enhances the secretion of cytokine interferon-gamma (IFN-g) and further induces
an anti-tumor immune response. HPV16 E7 plays an important role in the development
of certain types of cancer. 4-1BB, a surface glycoprotein of the tumor necrosis factor
receptor superfamily (TNFRSF), is an inducible costimulatory receptor that plays a
key role in T-cell proliferation, survival and cytolytic activity. IL-12 promotes
the activation of NK cells, which induces both the secretion of IFN-g and a CTL response
against the tumor cells.;
Molecule name : RTX-321; RTX 321;
NCI Metathesaurus CUI : CL1661942;
Origin ID : C179375;
UMLS CUI : C5555652;
Semantic type(s)
- concept_is_in_subset
- has_target
