Preferred Label : Prednisolone 21-Phosphate;
NCIt synonyms : Prednisolone 21-(dihydrogen phosphate); Prednisolone Phosphate; 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate); Prednisolone P-21;
NCIt definition : The phosphate ester form of prednisolone, a synthetic glucocorticoid with anti-inflammatory
and immunomodulating properties. As a glucocorticoid receptor agonist, prednisolone
21-phosphate binds to specific intracellular glucocorticoid receptors, and causes
the ligand-receptor complex to be translocated to the nucleus where it initiates the
transcription of glucocorticoid-responsive genes such as various cytokines and lipocortins.
Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic
acid from membrane phospholipids and preventing the synthesis of prostaglandins and
leukotrienes, both potent mediators of inflammation. This agent also decreases the
number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis
in sensitive tumor cell populations.;
UNII : 752SY38R6C;
InChIKey : JDOZJEUDSLGTLU-VWUMJDOOSA-N;
CAS number : 302-25-0;
Chemical formula : C21H29O8P;
Origin ID : C61904;
UMLS CUI : C1882444;
Currated CISMeF NLP mapping
- Semantic type(s)
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
