Preferred Label : Anti-netrin-1 Monoclonal Antibody NP137;
NCIt synonyms : Anti-NTN1 MoAB NP137;
NCIt definition : A recombinant humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against
the laminin-related protein netrin-1 (NTN1), with potential antineoplastic activity.
Upon administration, anti-NTN1 monoclonal antibody NP137 targets, binds to and neutralizes
NTN1, thereby preventing its binding to and activation of NTN1 receptors. By blocking
NTN1, NP137 is able to restore apoptosis in tumor cells. This inhibits tumor growth
and metastasis. NTN1, overexpressed by a variety of cancers, plays a key role in promoting
tumor initiation, progression, proliferation, adhesion, invasion, survival and modulation
of tumor F52:J54 plasticity and the tumor microenvironment (TME).;
Molecule name : NP-137; NP 137;
NCI Metathesaurus CUI : CL1661894;
Origin ID : C179293;
UMLS CUI : C5555591;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
