Preferred Label : CXCR4-modified Anti-BCMA CAR T Cells;
NCIt synonyms : CXCR4-modified Anti-BCMA CAR T-cells; CXCR4 Modified Anti-BCMA CAR-T Cells;
NCIt definition : A preparation of T-lymphocytes that have been genetically engineered to express a
chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell
maturation antigen (BCMA; TNFRSF17) with modification of the C-X-C chemokine receptor
type 4 (CXCR4), with potential immunomodulating and antineoplastic activities. Upon
administration, the CXCR4-modified anti-BCMA CAR T cells target and bind to tumor
cells expressing BCMA and induce selective cytotoxicity in those tumor cells. The
modification of the stromal-cell derived factor-1 (SDF-1 or CXCL12) receptor CXCR4
may improve the penetration of CAR T cells into the tumor microenvironment (TME).
BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating
factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF).
BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma
cells and plays a key role in plasma cell proliferation and survival.;
NCI Metathesaurus CUI : CL1661887;
Origin ID : C179284;
UMLS CUI : C5555583;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
