Preferred Label : Inetetamab;
NCIt synonyms : Trastuzumab Analogue Inetetamab;
NCIt definition : An Fc-engineered monoclonal antibody targeting the tyrosine kinase receptor epidermal
growth factor receptor 2 (HER2; ErbB2), with potential immunomodulating and antineoplastic
activities. Upon administration, inetetamab targets and specifically binds to HER2
on tumor cells, thereby blocking HER2-mediated signaling. This may inhibit proliferation
of HER2-expressing tumor cells. In addition, the Fab region of inetetamab may induce
antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells that overexpress
HER2. HER2 is overexpressed in a variety of cancer cell types and is associated with
increased tumor cell proliferation.;
Drug name : Cipterbin;
NCI Metathesaurus CUI : CL1661893;
Origin ID : C179282;
UMLS CUI : C5555581;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
