Preferred Label : STING Agonist SNX281;
NCIt definition : An agonist of the intracellular innate immune adaptor stimulator of interferon genes
protein (STING; transmembrane protein 173; TMEM173), with potential immunoactivating
and antineoplastic activities. Upon intravenous administration, STING agonist SNX281
targets and binds to STING and activates the STING pathway in immune cells in the
tumor microenvironment (TME). This leads to the production of pro-inflammatory cytokines,
including interferons (IFNs), enhances the cross-presentation of tumor-associated
antigens (TAAs) by antigen-presenting cells (ADCs), including dendritic cells (DCs),
and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer
cells. STING, a transmembrane protein that activates immune cells in the TME, plays
a key role in the activation of the innate immune system.;
Molecule name : SNX 281; SNX-281;
NCI Metathesaurus CUI : CL1661904;
Origin ID : C179271;
UMLS CUI : C5555571;
Semantic type(s)
- concept_is_in_subset
- has_target
