Anti-CD79b CAR T Cells

Preferred Label : Anti-CD79b CAR T Cells;

NCIt synonyms : CD79b CAR-T Cells;

NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell antigen receptor complex-associated protein beta chain (CD79b; B-cell-specific glycoprotein B29), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD79b CAR T cells target and bind to CD79b-expressing tumor cells, thereby inducing selective toxicity in CD79b-expressing tumor cells. CD79b, a critical receptor for successful B cell development and part of the B cell receptor (BCR) signaling complex, is widely expressed in certain subtypes of B cell lymphomas.;

NCI Metathesaurus CUI : CL1661905;

Details

Origin ID

C179270;

UMLS CUI

C5555570;

Semantic type(s)
- Cell [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- B-Cell Antigen Receptor Complex-Associated Protein Beta Chain [NCIt concept]

Keyword's position in hierarchy(ies) :

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