Preferred Label : Recombinant Human GM-CSF-encoding Oncolytic Adenovirus SynOV1.1;
NCIt synonyms : Oncolytic Virotherapeutic SynOV1.1;
NCIt definition : A recombinant oncolytic adenovirus, controlled by synthetic gene circuit, encoding
the human immunostimulating factor cytokine granulocyte-macrophage colony stimulating
factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Upon
administration, the recombinant human GM-CSF-encoding oncolytic adenovirus SynOV1.1
selectively targets, infects and replicates in tumor cells expressing the tumor-associated
antigen (TAA) alpha-fetoprotein (AFP), thereby expressing GM-CSF and inducing tumor
cell lysis. The lysis of cancer cells causes the release of cancer-specific antigens,
and triggers systematic anti-tumor immune responses. In addition, GM-CSF attracts
dendritic cells (DCs) and may further stimulate a cytotoxic T-cell response against
tumor cells, which results in immune-mediated tumor cell death. The gene circuit contains
a synthetic sensory switch that is under the control of a cancer-specific AFP promoter
and multiple microRNA inputs. The gene circuits are triggered to activate viral replication
and express hGM-CSF in AFP-expressing cancer cells, but not in normal cells.;
Molecule name : SynOV1.1;
NCI Metathesaurus CUI : CL1661930;
Origin ID : C179256;
UMLS CUI : C5555557;
Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
