Preferred Label : PI3K alpha/delta Inhibitor TQ-B3525;
NCIt synonyms : PI3K-alpha/delta Inhibitor TQ-B3525;
NCIt definition : An orally available selective inhibitor of the alpha and delta isoforms of phosphatidylinositol
3-kinase (PI3-kinase subunit alpha/delta; PI3K-alpha/delta; PI3Kalpha/delta), with
potential antineoplastic activity. Upon oral administration, PI3K alpha/delta inhibitor
TQ-B3525 selectively targets, binds to, and inhibits PI3K alpha and delta and prevents
the activation of the PI3K/AKT signaling pathway. This decreases proliferation of
and induces cell death in PI3K-alpha/delta over-expressing tumor cells. PI3K-alpha/delta
also plays a key role in the B-cell receptor (BCR) signaling pathway and the proliferation
of certain hematologic cancer cells. The targeted inhibition of PI3K-alpha/delta is
designed to preserve PI3K signaling in normal, non-neoplastic cells, thereby minimizing
serious side effects.;
Molecule name : TQ B3525; TQ-B3525;
NCI Metathesaurus CUI : CL1661919;
Origin ID : C179252;
UMLS CUI : C4733667;
Semantic type(s)
- concept_is_in_subset
- has_target
