Preferred Label : Corticosteroid-containing Eye Drop;
NCIt synonyms : Corticosteroid Ophthalmic Solution; Steroidal Eye Drops; Corticosteroid Eye Drop;
NCIt definition : A sterile ophthalmic solution containing a corticosteroid, with anti-inflammatory
activity. Upon application of the corticosteroid-containing eye drop into the eye,
the corticosteroid binds to cytoplasmic receptors, translocates to the nucleus and
subsequently initiates the transcription of glucocorticoid-responsive genes such as
lipocortins to inhibit phospholipase A2. This prevents the release of arachidonic
acid, a precursor to prostaglandins and leukotrienes, both important mediators in
the pro-inflammatory response mechanism.;
NCI Metathesaurus CUI : CL1662051;
Origin ID : C179240;
UMLS CUI : C5555548;
Semantic type(s)
- concept_is_in_subset
