Preferred Label : Raludotatug Deruxtecan;
NCIt synonyms : Anti-CDH6/DXd ADC DS-6000a; Anti-CDH6 ADC DS-6000a; Anti-CDH-6 ADC DS-6000a; Anti-CDH6 Antibody-drug Conjugate DS-6000a; R-DXd;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1)
monoclonal antibody against the tumor-associated antigen (TAA) cadherin-6 (CDH6; CDH-6)
conjugated to deruxtecan, which is comprised of an enzymatically cleavable tetrapeptide-based
linker and MAAA-1181a (DXd), the cytotoxic DNA topoisomerase I inhibitor derivative
of exatecan, with potential antineoplastic activity. Upon administration of raludotatug
deruxtecan, raludotatug targets and binds to CDH6-expressing tumor cells. Upon cellular
uptake and lysosomal degradation of the linker, DXd targets and binds to DNA topoisomerase
I, thereby stabilizing the cleavable complex between topoisomerase I and DNA, resulting
in DNA breaks, inhibition of DNA replication and apoptosis. This inhibits the proliferation
of CDH6-expressing tumor cells. CDH6, a member of the cadherin family and overexpressed
by a variety of cancers, plays a key role in tumor cell proliferation.;
UNII : BPQ010OFD7;
CAS number : 2610074-57-0;
Molecule name : DS-6000a; DS 6000a; DS-6000;
NCI Metathesaurus CUI : CL1662077;
Origin ID : C179214;
UMLS CUI : C5708883;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
- has_target
