" /> Fluorine F 18 FTC-146 - CISMeF





Preferred Label : Fluorine F 18 FTC-146;

NCIt synonyms : 18F-FTC-146; 18F-6-(3-fluoropropyl)-3-(2-(azepan-1-yl)ethyl)benzo[d]thiazol-2(3H)-one; (18)F-FTC-146; [18F]-FTC-146;

NCIt definition : A radioconjugate composed of the selective sigma-1 receptor (S1R) ligand FTC-146 labeled with the radionuclide fluorine F 18, with potential use as an imaging agent for S1R-expressing tumor cells upon positron emission tomography (PET)/computed tomography (CT). Upon administration, fluorine F 18 FTC-146 targets and selectively binds to S1R expressed on tumor cells. The S1R-expressing tumor cells can then be visualized using PET/CT. S1R, widely distributed in the central nervous system (CNS) and peripheral tissues, plays a key role in the modulation of ion channels and other neurotransmitter systems, and in restoring neuronal function. It is upregulated in inflammatory diseases and in a variety of cancers. 18F-FTC-146 shows excellent selectivity for the S1R over the sigma-2 receptor and vesicular acetylcholine transporter (VAChT).;

NCI Metathesaurus CUI : CL1662073;

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07/05/2025


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