Preferred Label : Autologous Cytokine-induced Killer Cells/Vaccinia Virus DD-CDSR CRX100;
NCIt synonyms : Autologous CIK Cells/vvDD-CDSR CRX100;
NCIt definition : A preparation of autologous cytokine-induced killer (CIK) cells that have been generated
ex vivo from killer cells treated with cytokines and infected with the oncolytic vaccinia
virus DD-CDSR (vvDD-CDSR; double-deleted vaccinia virus plus CD/SMR), with potential
immunomodulatory and antineoplastic activities. CIK cells are CD3- and CD56-positive,
non-major histocompatibility complex (MHC)-restricted, natural killer (NK)-like T-lymphocytes.
Upon infusion of autologous CIK cells/vvDD-CDSR CRX100, the CIK cells protect the
oncolytic virus vvDD-CDSR from immune attack and enhance the delivery of the oncolytic
virus to tumor cells. The oncolytic virus vvDD-CDSR preferentially targets and infects
tumor cells causing oncolysis. In turn, the lysed tumor cells release various tumor-associated
antigens (TAAs), which induce an immune response against the tumor cells.;
Molecule name : CRX-100; CRX 100;
NCI Metathesaurus CUI : CL1648455;
Origin ID : C179187;
UMLS CUI : C5555516;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
