Preferred Label : Doxycycline Hyclate Matrix Formulation;
NCIt synonyms : Doxycycline Hyclate Matrix Extended-release Formulation; Doxycycline Polymer-lipid Encapsulation Matrix Formulation;
NCIt definition : An extended release (ER) formulation composed of the hyclate salt form of doxycycline,
a synthetic, broad-spectrum tetracycline antibiotic, in a biodegradable, polymer-lipid
encapsulation matrix (PLEX), with antimicrobial activity. Following reconstitution
and administration in the surgical wound/incision, doxycycline is released from the
matrix over an extended period of time. Upon release, doxycycline reversibly binds
to the bacterial 30S ribosomal subunit, and blocks the binding of aminoacyl-tRNA to
the mRNA-ribosome complex. This leads to an inhibition of bacterial protein synthesis.
This may prevent surgical site infections.;
Drug name : D-PLEX;
NCI Metathesaurus CUI : CL1648454;
Origin ID : C179186;
UMLS CUI : C5555515;
Semantic type(s)
- concept_is_in_subset
