Aprinocarsen - CISMeF

Preferred Label : Aprinocarsen;

NCIt synonyms : Protein Kinase C-Alpha Antisense; DNA, d(P-thio)(GTTCTCGCTGGTGAGTTTCA);

NCIt related terms : ISIS 3521; DNA, d(P-thio)(G-T-T-C-T-C-G-C-T-G-G-T-G-A-G-T-T-T-C-A);

NCIt definition : A synthetic phosphorothioate oligodeoxynucleotide. As an antisense molecule, aprinocarsen hybridizes to the 3-untranslated region of the human protein kinase C (PKC-alpha) mRNA, thereby inhibiting PKC-alpha expression and growth of PKC-alpha-dependent tumor cells. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer.;

UNII : FMT95051CQ;

CAS number : 151879-73-1;

Drug name : Affinitak; Affinitac;

Molecule name : LY900003; ISIS 3521; CGP 64128A;

NSC code : 719337;

Codes from synonyms : CDR0000045945; 50609;

Details

Origin ID

C1788;

UMLS CUI

C1454590;

Currated CISMeF NLP mapping
- aprinocarsen [MeSH Supplementary Concept]
- aprinocarsen [MeSH concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ISIS 3521 [MeSH Supplementary Concept]
- ISIS 3521 [MeSH concept]
- aprinocarsen [MeSH Supplementary Concept]
- aprinocarsen [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Carboplatin/ISIS 3521/Paclitaxel [NCIt concept]
- Cisplatin/Gemcitabine/ISIS 3521 [NCIt concept]

Keyword's position in hierarchy(ies) :

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