Preferred Label : Cisplatin-E Therapeutic Implant;
NCIt synonyms : MP 5010 Therapeutic Implant; MP 5010 TI; Intradose MPI-5010; CDDP/epi gel; MPI 5010; CDDP-e therapeutic implant; Cisplatin/Epinephrine Gel; Cisplatin-Epinephrine; CDDP/epi; Intradose; CEG;
NCIt definition : An injectable gel comprised of a collagen matrix containing the inorganic platinum
(Pt) agent cisplatin and the sympathomimetic agent epinephrine with potential antineoplastic
activity. After intratumoral injection, cisplatin forms highly reactive, positively
charged, platinum complexes, which covalently bind to nucleophilic groups in DNA,
preferably at the N7 position of guanine bases. This induces both intra- and inter-strand
DNA cross-links. In addition, cisplatin forms DNA-Pt-protein cross-links. Cross-link
formation results in both the induction of apoptosis and cell growth inhibition. Epinephrine,
a potent vasoconstrictor, is added to the gel to both enhance the penetration of cisplatin
into tumor tissue and reduce its dispersion into the surrounding tissues. Intratumoral
injection of cisplatin-E therapeutic implant may increase local chemotherapeutic efficacy,
as compared to the systemic administration of cisplatin, while reducing its systemic
toxicity.;
Origin ID : C17879;
UMLS CUI : C0677669;
Semantic type(s)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
