Preferred Label : Fluorouracil-E Therapeutic Implant;
NCIt synonyms : 5-FU/epi gel; Fluorouracil-epinephrine therapeutic implant; 5-FU-e TI; 5-Fluorouracil/epi; Fluorouracil/epi;
NCIt definition : An injectable collagen matrix gel containing the antimetabolite fluorouracil and the
sympathicomimetic agent epinephrine with potential antineoplastic activity. After
intratumoral injection, fluorouracil is converted into the active metabolite 5-fluoroxyuridine
monophosphate that competes with uracil during RNA synthesis while another active
metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate, inhibits thymidylate synthase
and, so, DNA synthesis. Epinephrine, a potent vasoconstrictor, is added to the gel
to enhance penetration of fluorouracil into tumor tissue and reduce dispersion to
surrounding tissues, thus enhancing the local concentration of fluorouracil. Compared
to systemic administration, the intratumoral injection of fluorouracil combined with
epinephrine may increase fluorouracil's chemotherapeutic efficacy while minimizing
systemic toxicity.;
Origin ID : C17877;
UMLS CUI : C0281426;
Semantic type(s)
- concept_is_in_subset
