Preferred Label : Methotrexate-E Therapeutic Implant;
NCIt synonyms : MTX-e TI; MTX/epi gel; Methotrexate-epinephrine therapeutic implant; Methotrexate/epi;
NCIt definition : An injectable collagen matrix gel containing the antimetabolite methotrexate and the
sympathicomimetic agent epinephrine with potential antineoplastic activity. After
intratumoral injection, methotrexate binds to and inhibits the enzyme dihydrofolate
reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis
and, subsequently, inhibition of DNA and RNA syntheses. Epinephrine, a potent vasoconstrictor,
is added to the gel to enhance penetration of methotrexate into the tumor tissue and
reduce dispersion to the surrounding tissues thereby enhancing the local concentration
of methotrexate and increasing its anti-tumor activity. Intratumoral injection of
methotrexate combined with epinephrine may potentially increase chemotherapeutic efficacy
compared to systemic administration and reduce systemic toxicity and side effects.;
Origin ID : C17876;
UMLS CUI : C0281425;
Semantic type(s)
- concept_is_in_subset
