Preferred Label : Nanoparticle SN-38-encapsulated Micelle Formulation SNB-101;
NCIt synonyms : SN-38-containing Nano-particle SNB-101; SN-38-containing Nano-sized Micelle Formulation SNB-101; Nanoparticle Formulation SNB-101;
NCIt definition : A nanoparticle-based formulation consisting of double core-shell (DUCS) micelles containing
7-ethyl-10-hydroxy-camptothecin (SN-38), the active, hydrophobic metabolite of the
prodrug irinotecan, with potential antineoplastic activity. Upon intravenous administration,
nanoparticle SN-38-encapsulated micelle formulation SNB-101 diffuses into the tumor
site and the SN-38 moiety binds to and inhibits topoisomerase I by stabilizing the
cleavable complex between topoisomerase I and DNA, which results in DNA breaks, inhibition
of DNA replication, and apoptosis. Compared to SN-38 alone, this formulation increases
the water solubility of the poorly soluble drug SN-38, and due to the stability of
this formulation, it has a much longer circulation time and reduces toxicity to normal,
healthy tissues.;
Molecule name : SNB 101; SNB-101;
NCI Metathesaurus CUI : CL1648286;
Origin ID : C178643;
UMLS CUI : C5555168;
Semantic type(s)
- concept_is_in_subset
