Preferred Label : W_pro1 Cancer Vaccine;
NCIt synonyms : WP1 Cancer Vaccine; RNA-LPX BNT112; RNA-lipoplex Vaccine BNT112; RNA-lipoplex Cancer Vaccine BNT112;
NCIt definition : A messenger ribonucleic acid (mRNA)-based cancer vaccine that encodes five prostate
cancer-selective off-the-shelf shared antigens that are separately complexed with
liposomes to form serum-stable RNA lipoplexes (RNA-LPX), with potential immunomodulating
and antineoplastic activities. Upon intravenous administration of the W_pro1 cancer
vaccine, the RNA-LPX are taken up by antigen-presenting cells (APCs), especially dendritic
cells (DCs). Upon uptake, the antigens are translated, processed, and presented to
the immune system on major histocompatibility complex (MHC) class I and II molecules.
This may activate the immune system to induce both an adaptive and innate immune response
against cancer cells expressing these five antigens.;
Molecule name : BNT-112; Wpro1; BNT 112; W_pro1; W pro1;
NCI Metathesaurus CUI : CL1648300;
Origin ID : C178636;
UMLS CUI : C5555167;
Semantic type(s)
- concept_is_in_subset
