Preferred Label : Anti-TROP2 Monoclonal Antibody-Tub196 Conjugate JS108;
NCIt synonyms : ADC JS108; Anti-TROP2 ADC JS108; Anti-Trop-2 Antibody-drug Conjugate JS108; Anti-TROP2-Tub196 ADC JS108;
NCIt definition : An antibody-drug conjugate (ADC) composed of a recombinant humanized monoclonal antibody
against tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast
antigen 2; calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) conjugated,
via a 2,3-disubstituted long side chain hydrolysis-resistant linker, to the tubulysin
B analog Tub196, with potential antineoplastic activity. Upon administration of the
anti-TROP2 monoclonal antibody-Tub196 conjugate JS108, the anti-TROP2 antibody targets
and binds to TROP2 expressed on tumor cells. Upon cellular uptake, the cytotoxic tubulysin
B analog binds to tubulin, thereby affecting microtubule assembly and disassembly
dynamics. This inhibits microtubule polymerization, which blocks cell division and
results in G2/M phase arrest, tumor cell apoptosis and a decrease in proliferation
of TROP2-expressing tumor cells. TROP2 is a transmembrane protein overexpressed in
various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis,
drug resistance, increased tumor cell survival and poor prognosis.;
Molecule name : JS-108; JS 108;
NCI Metathesaurus CUI : CL1648086;
Origin ID : C178576;
UMLS CUI : C5555140;
Semantic type(s)
- concept_is_in_subset
