Preferred Label : BCMA-specific Universal CAR-expressing T-lymphocytes LCAR-BCX;
NCIt synonyms : BCMA-targeted Universal LCAR-BCX Cells; LCAR-BCX Cells;
NCIt definition : A preparation of universal T-lymphocytes that have been genetically modified to express
a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell
maturation antigen (BCMA), with potential immunostimulating and antineoplastic activities.
Upon intravenous administration, BCMA-specific universal CAR-expressing T-lymphocytes
LCAR-BCX are directed to cells expressing BCMA and induce selective toxicity in BCMA-expressing
tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and
B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor
superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is overexpressed
on malignant plasma cells.;
Molecule name : LCAR-BCX;
NCI Metathesaurus CUI : CL1648085;
Origin ID : C178575;
UMLS CUI : C5557524;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
