Preferred Label : Allogeneic Invariant Natural Killer T-cells agenT-797;
NCIt synonyms : Allogeneic iNKT agenT-797;
NCIt definition : A preparation of allogeneic, off-the shelf, natural killer T-cells (NKTs) expressing
an invariant (alpha, beta) T-cell receptor (iNKTs), with potential immunomodulating
and antineoplastic activities. Upon administration of allogeneic iNKT agenT-797, the
invariant T-cell receptor (TCR) and natural-killer group 2, member D receptor (NKG2D;
KLRK1; natural killer cell activating receptor group 2D) expressed by these cells
recognize CD1d-restricted lipid ligands and stress ligands, which are expressed on
certain tumor cells. These receptor-ligand interactions may induce the secretion of
large amounts of various pro-inflammatory cytokines, including interferon gamma (IFN-g),
and activate the immune system against tumor cells. Additionally, iNKTs directly target
and lyse tumor cells.;
Molecule name : AGENT-797; AGENT 797;
NCI Metathesaurus CUI : CL1648033;
Origin ID : C178501;
UMLS CUI : C5555088;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
