Preferred Label : Prifetrastat;
NCIt synonyms : KAT6 Inhibitor PF-07248144;
NCIt definition : An inhibitor of MYST histone acetyltransferase (HAT) KAT6, with potential antineoplastic
activity. Upon administration, prifetrastat targets and binds to KAT6, and inhibits
the acetylation of histones and other nonhistone substrates. This may disrupt gene
expression and inhibit the proliferation of tumors that overexpress KAT6. KAT6A (MOZ;
MYST3) and KAT6B (MORF; MOZ2; MYST4), commonly amplified genes in solid tumors, play
key roles in cell cycle regulation and in tumorigenesis.;
UNII : GN6DU4ZE30;
CAS number : 2569008-99-5;
Molecule name : PF 07248144; PF-07248144;
NCI Metathesaurus CUI : CL1648113;
Origin ID : C178474;
UMLS CUI : C5555065;
Semantic type(s)
- concept_is_in_subset
- has_target
