Preferred Label : KAT6 Inhibitor PF-07248144;
NCIt definition : An inhibitor of MYST histone acetyltransferase (HAT) KAT6, with potential antineoplastic
activity. Upon administration, KAT6 inhibitor PF-07248144 targets and binds to KAT6,
and inhibits the acetylation of histones and other nonhistone substrates. This may
disrupt gene expression and inhibit the proliferation of tumors that overexpress KAT6.
KAT6A (MOZ; MYST3) and KAT6B (MORF; MOZ2; MYST4), commonly amplified genes in solid
tumors, play key roles in cell cycle regulation and in tumorigenesis.;
Molecule name : PF 07248144; PF-07248144;
NCI Metathesaurus CUI : CL1648113;
Origin ID : C178474;
UMLS CUI : C5555065;
Semantic type(s)
- concept_is_in_subset
- has_target
