Anti-VISTA Monoclonal Antibody W0180

Preferred Label : Anti-VISTA Monoclonal Antibody W0180;

NCIt definition : A humanized immunoglobulin (Ig) G1 monoclonal antibody directed against the negative immune checkpoint regulatory protein V-domain Ig suppressor of T-cell activation (VISTA; programmed death 1 homolog; PD1H; PD-1H), with potential negative immune checkpoint regulatory and antineoplastic activities. Upon administration, anti-VISTA monoclonal antibody W0180 targets and binds to the extracellular domain of VISTA on myeloid cells and T-cells within the tumor microenvironment (TME). This inhibits VISTA-mediated signaling, decreases the presence of monocytic myeloid-derived suppressor cells (MDSCs), increases the presence of natural killer cells (NKs), activates dendritic cells (DCs) and abrogates VISTA-induced suppression of T-lymphocyte immune responses. This enhances cytotoxic T-cell infiltration, proliferation and activation within the TME, increases cytokine production by T-cells, and inhibits tumor cell growth. VISTA, a negative checkpoint molecule of immune activation, is highly expressed on myeloid cells, T-cells and in several tumor types. It plays a key role in the suppression of T-cell function.;

Molecule name : W 0180; W-0180;

NCI Metathesaurus CUI : CL1647859;

Details

Origin ID

C178407;

UMLS CUI

C5555014;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- V-Type Immunoglobulin Domain-Containing Suppressor of T-Cell Activation [NCIt concept]

Keyword's position in hierarchy(ies) :

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