Preferred Label : HPV16 E6/7 mRNA Vaccine BNT113;
NCIt synonyms : RNA-LPX HPV16 E6/7 Vaccine BNT113; RNA-lipoplex Vaccine BNT113; RNA-lipoplex Cancer Vaccine BNT113; RNA-LPX BNT113; E6/E7 RNA(LIP) BNT113;
NCIt definition : A RNA-lipoplex (RNA-LIP)-based cancer vaccine containing messenger RNA (RNA) encoding
for the human papillomavirus type 16 (HPV-16) oncoproteins E6 and E7, encapsulated
in liposomes, with potential immunomodulating and antineoplastic activities. Upon
intravenous administration of the HPV16 E6/7 mRNA vaccine BNT113, the liposomes protect
the RNA from degradation in the bloodstream, travel to the spleen and are taken up
by antigen-presenting cells (APCs), especially dendritic cells (DCs). The RNA is translocated
to the cytoplasm and translated into the E6 and E7 oncoproteins. The expressed proteins
are processed and the human leukocyte antigen (HLA)-peptide complexes are presented
to the immune system. This results in the induction of antigen-specific CD8 and CD4
T-cell responses against HPV16 E6 and E7. The viral neoantigens HPV16 E6 and E7 are
found in HPV16-positive cancers.;
Molecule name : BNT-113; BNT 113;
NCI Metathesaurus CUI : CL1647863;
Origin ID : C178403;
UMLS CUI : C5555010;
Semantic type(s)
- concept_is_in_subset
- has_target
