Preferred Label : Risovalisib;
NCIt synonyms : PI3K-alpha Inhibitor CYH33; PI3Kalpha Inhibitor CYH33;
NCIt definition : An orally bioavailable selective inhibitor of the class I phosphatidylinositol-4,5-bisphosphate
3-kinase (PI3K) catalytic subunit alpha (PIK3CA), with potential antineoplastic activity.
Upon administration, risovalisib selectively targets, binds to and inhibits wild-type
PIK3CA and its mutated forms, in the PI3K/Akt (protein kinase B) /mammalian target
of rapamycin (mTOR) pathway. This results in both apoptosis and growth inhibition
in PIK3CA-expressing tumor cells. By specifically targeting PIK3CA, this agent may
be more efficacious and less toxic than pan-PI3K inhibitors. Dysregulation of the
PI3K/Akt/mTOR pathway is often found in solid tumors and results in the promotion
of tumor cell growth, survival, and resistance to chemo- and radio-therapy. PIK3CA,
one of the most frequently mutated oncogenes, encodes the p110-alpha catalytic subunit
of the class I PI3K.;
UNII : RCA38L4HB5;
CAS number : 1494684-28-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1494684-28-4
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : CYH-33; HH-CYH33; CYH 33; HHCYH 33;
NCI Metathesaurus CUI : CL1647865;
Origin ID : C178401;
UMLS CUI : C5226943;
Semantic type(s)
- UMLS correspondences (same concept)
- CYH33 [MeSH Supplementary Concept]
- concept_is_in_subset
- has_target
