Preferred Label : Oxygen Carrier YQ23;
NCIt synonyms : Hemoglobin-based Oxygen Carrier YQ23;
NCIt definition : A bovine-derived, stabilized, non-polymeric, cross-linked, tetrameric hemoglobin-based
oxygen carrier, with potential oxygen carrying, immunomodulating and antineoplastic
activities. Upon administration, oxygen carrier YQ23 may increase the oxygen level
in the tumor microenvironment (TME). This may prevent the increase of circulating
endothelial progenitor cells (EPCs) and regulatory T-cells (Tregs) that results from
tissue ischemia and hypoxia. EPCs play important roles in tumor vasculogenesis, tumor
growth and metastases. Tregs play an important role in antitumor immune responses.;
Molecule name : YQ 23; YQ-23;
NCI Metathesaurus CUI : CL1647824;
Origin ID : C178342;
UMLS CUI : C5554967;
Semantic type(s)
- concept_is_in_subset
