Recombinant HSA/G-CSF Fusion Protein MW05

Preferred Label : Recombinant HSA/G-CSF Fusion Protein MW05;

NCIt definition : A recombinant fusion protein composed of human serum albumin (HSA) fused to human granulocyte colony stimulating factor (G-CSF), with potential granulopoietic activity. Upon administration, recombinant HSA/G-CSF fusion protein MW05 mimics endogenous G-CSF that is produced by monocytes, fibroblasts, and endothelial cells. G-CSF binds to and activates specific cell surface receptors, thereby stimulating the proliferation, differentiation, function, and survival of neutrophil precursors and mature neutrophils. This may prevent granulocytopenia. HSA fusion increases the molecular weight of G-CSF, prolongs its half-life and masks G-CSF, thereby preventing G-CSF degradation which further increases the half-life and bioavailability of G-CSF.;

Molecule name : MW 05; MW-05;

NCI Metathesaurus CUI : CL1647835;

Details

Origin ID

C178333;

UMLS CUI

C5554958;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Hematopoietic Stem Cell [NCIt concept]
chemical_or_drug_affects_gene_product
- GM-CSF Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Cell Differentiation [NCIt concept]
- Receptor Activation Process [NCIt concept]
- Stimulation of Cell Proliferation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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