Preferred Label : Recombinant HSA/G-CSF Fusion Protein MW05;
NCIt definition : A recombinant fusion protein composed of human serum albumin (HSA) fused to human
granulocyte colony stimulating factor (G-CSF), with potential granulopoietic activity.
Upon administration, recombinant HSA/G-CSF fusion protein MW05 mimics endogenous G-CSF
that is produced by monocytes, fibroblasts, and endothelial cells. G-CSF binds to
and activates specific cell surface receptors, thereby stimulating the proliferation,
differentiation, function, and survival of neutrophil precursors and mature neutrophils.
This may prevent granulocytopenia. HSA fusion increases the molecular weight of G-CSF,
prolongs its half-life and masks G-CSF, thereby preventing G-CSF degradation which
further increases the half-life and bioavailability of G-CSF.;
Molecule name : MW 05; MW-05;
NCI Metathesaurus CUI : CL1647835;
Origin ID : C178333;
UMLS CUI : C5554958;
Semantic type(s)
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
