Astatine At 211 F(ab')2 MX35

Preferred Label : Astatine At 211 F(ab')2 MX35;

NCIt synonyms : Astatine At 211-MX35 F(ab')2; 211-Astatine-MX35 F(ab')2; At211-MX35 F(ab')2; 211 At Astatine-labeled MX35 F(ab')2;

NCIt definition : A radioimmunoconjugate composed of the F(ab')2 fragment of monoclonal antibody MX35 targeting the sodium-dependent phosphate transport protein 2b (NaPi2b; SLC34A2) labeled with the alpha-emitting radionuclide astatine (At) 211 (211At), with potential antineoplastic activity. Upon administration of astatine At 211 F(ab')2 MX35, the F(ab')2 MX35 moiety targets and binds to NaPi2b-expressing tumor cells, thereby delivering a cytotoxic dose of alpha radiation directly to the NaPi2b-expressing tumor cells. NaPi2b, a multi-transmembrane, sodium-dependent phosphate transporter, is highly expressed in certain types of tumor cells.;

NCI Metathesaurus CUI : CL1647839;

Details

Origin ID

C178329;

UMLS CUI

C5554954;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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