Preferred Label : IRDye800CW-Nimotuzumab;
NCIt synonyms : Nimotuzumab-IRDye800CW; IRDye800CW-labeled Nimotuzumab;
NCIt definition : A fluorescence imaging and contrast agent and immunoconjugate comprised of nimotuzumab,
a humanized monoclonal antibody directed against the epidermal growth factor receptor
(EGFR), conjugated to the near-infrared (NIR) fluorescent dye IRDye 800CW, with potential
imaging use. Upon administration of IRDye800CW-nimotuzumab, the nimotuzumab moiety
targets and binds to the extracellular domain of EGFR. Upon binding, IRDye 800 may
be detected using NIR imaging, which facilitates the visualization and detection of
EGFR-expressing tumor cells. EGFR is a receptor tyrosine kinase that may be overexpressed
on the cell surfaces of various tumor types.;
NCI Metathesaurus CUI : CL1647812;
Origin ID : C178322;
UMLS CUI : C5554948;
Semantic type(s)
- concept_is_in_subset
