Preferred Label : Ribocytokine IL-2 BNT151;
NCIt synonyms : Modified Recombinant Human Interleukin-2 BNT151;
NCIt definition : A formulation consisting of nucleoside-modified messenger RNA (mRNA) encoding a modified
form of the endogenous cytokine interleukin-2 (IL-2), with potential immunostimulating
activity. Upon administration, ribocytokine IL-2 BNT151 is taken up by cells and the
expressed IL-2 targets and binds to the IL-2 receptor beta subunit (IL2Rb; IL2Rbeta;
CD122). The binding of IL-2 to IL2Rb activates IL2Rb-mediated signaling, which activates
cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells, and induces expression
of certain cytotoxic cytokines, such as interferon-gamma (IFNg) and transforming growth
factor-beta (TGFb). The specific induction of T-cell-mediated cytotoxic immune responses
against tumor cells causes tumor cell destruction. IL2Rb plays a key role in the proliferation
and activation of effector T-cells.;
Molecule name : BNT-151; BNT 151;
NCI Metathesaurus CUI : CL1647817;
Origin ID : C178319;
UMLS CUI : C5554945;
Semantic type(s)
- concept_is_in_subset
