Autologous mRNA-encoding NSCLC Neoantigens Dendritic Cell Vaccine

Preferred Label : Autologous mRNA-encoding NSCLC Neoantigens Dendritic Cell Vaccine;

NCIt synonyms : MIDRIXNEO-LUNG Autologous DC Vaccine; Autologous mRNA-loaded NSCLC DC Vaccine; Autologous MIDRIXNEO-LUNG Dendritic Cell Vaccine;

NCIt definition : A dendritic cell (DC)-based cancer vaccine in which the autologous, in vitro activated DCs are loaded with messenger RNA (mRNA) encoding neoantigens from the patient's non-small cell lung cancer (NSCLC), with potential immunomodulating and antineoplastic activities. Upon administration of autologous mRNA-encoding NSCLC neoantigens DC vaccine, the mRNA gets expressed into neoantigens in cells and the neoantgens activate the immune system to induce robust neoantigen-specific T-cell responses against the NSCLCs expressing these neoantigens. The neoantigens are predicted from the patient-individual tumor's mutanome.;

NCI Metathesaurus CUI : CL1647938;

Details

Origin ID

C178309;

UMLS CUI

C5554936;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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