Preferred Label : Partially HLA-matched AdV/CMV/EBV/BKV-specific Allogeneic T-lymphocytes;
NCIt synonyms : HLA-matched Multivirus-specific Cytotoxic T-Lymphocytes; Allogeneic AdV/CMV/EBV/BKV Virus-specific T Cells; Allogeneic AdV/CMV/EBV/BKV VSTs; HLA-matched VSTs;
NCIt definition : A preparation of partially human leukocyte antigen (HLA)-matched allogeneic cytotoxic
T-lymphocytes (CTLs) that are specifically reactive to the four viruses adenovirus
(AdV), cytomegalovirus (CMV), Epstein-Barr virus (EBV) and human polyomavirus type
I (BKV), with potential antiviral activity. Upon infusion of the partially HLA-matched
AdV/CMV/EBV/BKV-specific allogeneic T-lymphocytes upon allogeneic hematopoietic stem
cell transplantation (HSCT) in an immunodeficient recipient, these CTLs may kill AdV,
CMV, EBV and/or BKV-infected cells, and may prevent or reduce the severity of viral
infections by these pathogens.;
NCI Metathesaurus CUI : CL1647950;
Origin ID : C178297;
UMLS CUI : C5554926;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
